In agreement with the importance of AXL, HER2, and HER3 to EGFR-TKI sensitivity in NSCLC [14,15,16,17,19,21], LDOC1 depletion reduced EGFR-TKI sensitivity in PC9 and HCC827 cells (Figure 6a,b). This evidence concerns the gene EGFR and non-small cell lung carcinoma.