We further propose that the Lod domain may represent a unique self-assembled macromolecular target for future drug interventions that aim to prevent toxic amylin, tau, and amylin-tau oligomers attachment to the host cell membranes in T2D [3], AZ [1], and the cross-talk between T2D and AZ [4,5,6,19], accordingly. Here, MAPT is linked to type 2 diabetes mellitus.