PTEN and colonic neoplasm: Difluorinated curcumin, an analogue of curcumin isolated from Curcuma longa L., displayed antiproliferative activity against 5-fluorouracil (5-FU) + Oxaliplatin-resistant colon cancer cells, downregulated miR21 in chemo-resistant colon cancer (HCT116 and HT-29) cells, and restored PTEN function [74].