ADIPOQ and diabetes mellitus: The non-polar extracts of T. sinensis leaves (TSLs) prepared using supercritical-CO2 fluid have been shown to prevent the progression of DM and liver fibrosis, increase triglyceride levels and decrease adiponectin levels in low-dose streptozotocin (STZ)-induced mice with type-2 diabetes mellitus (T2DM) [52].