The potential of L. plantarum Q16 to increase the expression of adipose triglyceride lipase (ATGL) and reduce the expression of diacylglycerol acyltransferase 1 (DGAT1) in the liver is further beneficial for NAFLD mitigation by inhibiting the hepatic TG synthesis. The gene discussed is PNPLA2; the disease is metabolic dysfunction-associated steatotic liver disease.