Also, in adipose tissue, PPAR-γ increases the secretion of adiponectin that can ameliorate NAFLD by promoting hepatic insulin sensitivity and β-oxidation, restricting hepatic gluconeogenesis, and suppressing the production of proinflammatory cytokine tumor necrosis factor (TNF)-α [76]. The gene discussed is PPARG; the disease is metabolic dysfunction-associated steatotic liver disease.