STAT3 and cancer: In addition, it has also been found to interfere with the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), signal transducer and activator of transcription 3 (STAT3), epidermal growth factor receptor (EGFR), mammalian target of rapamycin (mTOR), epithelial-mesenchymal transition (EMT), and Sonic hedgehog (SHH) signal pathway of the cancers [11,13,14,15].