Liposomes can reach tumor sites passively through the EPR effect [23], while surface-modified (or surface-engineered) liposomes act by binding to specific receptors overexpressed by cancer cells, such as epidermal growth factor receptor (EGFR), folate receptor (FR), transferrin receptor (TFR), and other receptors (Figure 3) [22]. Here, EGFR is linked to neoplasm.