ABCB4 and breast cancer: Research by Wen et al. evaluated the effect of curcumin on doxorubicin chemoresistance in breast cancer cells, verifying curcumin reduced ABCB4-overexpressing cells efflux of doxorubicin, suppressing ABCB4 ATPase activity, which resulted in an increased accumulation of doxorubicin [71].