Various benzimidazole derivatives with anticancer activity target different aspects of cancer cells, including DNA (through intercalation or alkylation), topoisomerases, poly (ADP ribose) polymerase (PARP), dihydrofolate reductase (DHFR), protein kinases and phosphatases, androgen receptors, and microtubules [7]. The gene discussed is DHFR; the disease is cancer.