The mechanistic correlation of specific components and hyperhidrosis targets of floating wheat through network pharmacology reveals that vanillol, cumaric acid, ENOXOLONE, abscisic acid, secoisolariciresinol, kaempferol, and stigmasterol have a modulatory effect on hyperhidrosis, and protein targets ESR1, ESR2, and MAP2K1 were found to be the potential targets of floating wheat for the treatment of hyperhidrosis in menopause. The gene discussed is ESR1; the disease is Hyperhidrosis.