Subsequently, zar1 has been identified in more than ten species, including rats (Rattus norvegicus) [12], cattle (Bos taurus) [13], pigs (Sus scrofa) [14], rabbits (Leporidae) [15], chickens (Gallus gallus) [16], pufferfish (Tetraodontidae) [12], African Xenopus (Xenopus laevis) [17], zebrafish (Danio rerio) [18], etc. Zar1 has conserved ovarian localization [19], and it may also have some non-ovarian functions, because it is expressed in some non-ovarian organs, such as the lung, spleen, kidney and heart [13,14,15,20,21]; the zar1 gene is also expressed in cancer cells [22,23,24]. The gene discussed is ZAR1; the disease is cancer.