Raslan et al. reported a novel class of 2-oxo-pyridine and 1′H-spiro-pyridine derivatives as new apoptosis-inducing agents against a colorectal adenocarcinoma (Caco-2) cell line by activation of BAX and deactivation of BCL-2 genes [81]. This evidence concerns the gene BCL2 and colorectal adenocarcinoma.