Considering that hypertension is a progressive disease that triggers other chronic diseases such as cardiovascular disease and stroke [13], it is important to study the renin–angiotensin system, which regulates blood pressure as follows: renin activates angiotensinogen to produce angiotensin I, which is subsequently converted to angiotensin II by the action of the ACE enzyme. The gene discussed is REN; the disease is hypertensive disorder.