In a murine study of pituitary gland inflammation, site-specific deposition of C3 and C4 on prolactin- and TSH-secreting pituitary cells preferentially expressing CTLA-4 was observed, and anti-TSH and anti-PRL auto-antibodies were subsequently elevated in the serum of patients who developed hypophysitis after receiving ipilimumab [77]. This evidence concerns the gene PRL and hypophysitis.