PRKAG2 and Wolff-Parkinson-White syndrome: On clinical evaluation, the high-risk features include male sex, familial WPW syndrome (autosomal dominant, chromosome 7, PRKAG2 gene mutation), WPW pattern detected in the first two decades of life, history of atrial fibrillation and arrhythmic symptoms like syncope, and presence of congenital heart disease, especially, Ebstein’s anomaly.