Finally, the breast cancer and DNA damage response (only ATM dependent) pathways were enriched WikiPathways, together with PI3K-AKT-mTOR signaling pathway and therapeutic opportunities, EGFR tyrosine kinase inhibitor resistance, apoptosis as well as the androgen and estrogen receptor signaling pathways (Supplementary File S2E). The gene discussed is AKT1; the disease is breast carcinoma.