F8 and Venous thrombosis: The factors that increase the risk of thrombosis were identified as hypertension (blood pressure greater than 140/90 mm Hg), obesity (Body Mass Index (BMI) greater than 30), hypercholesterolemia (serum LDL greater than 3 mmol/L), smoking, diabetes mellitus, atrial fibrillation (AF), a family history of thrombosis, being HIV-positive, experiencing trauma or major surgery, and receiving recent FVIII/FIX infusion [28,29].