F8 and hemophilia: Additionally, treatment-related complications, such as FVIII inhibitors, chronic liver disease, human immunodeficiency virus (HIV)-associated thrombocytopenia, NSAID-induced gastritis [25] and thrombocytopathy, and environmentally acquired infectious diseases, including Helicobacter pylori gastritis, intestinal helminthiasis, and urinary schistosomiasis, can exacerbate the bleeding tendency in hemophilia [21,25,26].