Cases included invasive breast cancers of the histological subtypes NST (no special type, ductal carcinoma) and lobular carcinoma, of low, intermediate, or high grade, with or without expression of the estrogen and/or progesterone receptor, of HER2 positive or negative status, and of high or low proliferation rate (Ki67) to avoid sample bias. The gene discussed is MKI67; the disease is breast ductal adenocarcinoma.