FOS and anxiety disorder: A protective effect of lignans against the effects of chronic stress-induced anxiety disorders resulting from modulating dopamine, norepinephrine, and serotonin levels, c-Fos expression, and corticosterone levels, as well as inhibiting the enzymatic activity of MAO-A monoxidase responsible for the deamination of serotonin, adrenaline, and norepinephrine dopamine and tyramine, and MAO-B monoxidase showing affinity for dopamine and serotonin, has also been observed in animal models [60,74,75].