However, owing to associated side effects such as skin rashes, systemic vasculitis, gastrointestinal, hepatic, and renal toxicity [12], coupled with an increasing hyperuricemia-suffering population, there is a growing demand for novel natural substances with better inhibitory activity against xanthine oxidase and fewer side effects compared to allopurinol and febuxostat. The gene discussed is XDH; the disease is hyperuricemia.