Higher levels of the protein F7 (coagulation factor VII) have been linked to cardiovascular disease and obesity [43], while previous research indicates that proteins ACY1 (aminocyclase 1) and GSTA1 (glutathione S-transferase alpha 1) are positively associated with T2D [44,45]. This evidence concerns the gene ACY1 and obesity due to melanocortin 4 receptor deficiency.