In this follow-up research, we observed the interaction of these gene polymorphisms (COMT, GSTM1, GSTT1, MGMT, NQO1, and XRCC1) with different meat diets and on outcomes linked to colorectal cancer risk: ATNC levels, DNA adduct levels, and DNA strand breaks. The gene discussed is XRCC1; the disease is colorectal cancer.