Regurgitation, vomiting, crying, fussiness, diarrhea and poor appetite have been reported in both LI and non-IgE-mediated CMA, which might also mimic pediatric functional gastrointestinal disorders (FGIDs), gastroesophageal reflux disease (GERD), eosinophilic esophagitis (EoE), anatomic abnormalities or metabolic and neurological diseases. Here, IGHE is linked to gastroesophageal reflux disease.