VDR and acute myeloid leukemia: A further indication of the impact of VDR and 1,25(OH)2D3 on the differentiation of the myeloid line of hematopoiesis is the observation that high VDR gene expression is associated with a good prognosis of AML (acute myeloid leukemia) and that synthetic VDR ligands are promising disease-modifying drugs [50].