CD4 and colitis: In facts, colitis murine models, such as IL10 knock-out mice, have shown higher levels of IgG against foods compared to controls; furthermore, the administration of beta-conglycinin, identified as an antigenic food protein, induced CD4(+) T-cell production of interferon-γ and IL-17 in the same murine model, leading to worse and more severe colitis [114].