Furthermore, in asthmatic patients an up-regulation of miR-27b-3p in blood samples compared to healthy controls was found and it was showed, through bioinformatic analysis, that serpin family E member 1 (SERPINE1) and RAR-related orphan receptor A (RORA) are genes target of miR-27b-3p, which are genes associated with allergic asthma [45]. The gene discussed is SERPINE1; the disease is allergic asthma.