IL6 and asthma: In human small airway epithelial cells (HSAECs) stimulated with platelet-activating factor (PAF), an inductor of the inflammatory response, downregulation of miR-146a-5p expression was promoted [76], while the overexpression of miR-146a-5p in PAF-stimulated HSAECs induced a reduction in airway inflammation (IL-1β, Il-6, and TNF-α) and cell barrier damage (apoptosis) in asthma by targeting TNF receptor-associated factor 6 (TRAF6) (Figure 3a) [76].