Interestingly, in our study, neither the use of a probiotic nor the eradication of SIBO had a significant effect on the level of a biomarker of intestinal barrier dysfunction claudin 3 [46] in cirrhosis, which shows that SIBO is likely not associated with this intestinal pathology in cirrhosis; the tested probiotic also did not have a significant effect on the intestinal barrier. The gene discussed is CLDN3; the disease is Cirrhosis.