These JAK2 translocations (e.g., PCM1-JAK2, ETV6-JAK2, and BCR-JAK2) and FLT3 translocations (e.g., ETV6-FLT3, BCR-FLT3, and FLT3-TRIP11) are less common than PDGFRB translocations, generally manifesting as chronic myeloproliferative disease (e.g., CEL, aCML or CMML with eosinophilia), acute lymphoblastic leukemia, and very rarely as AML with eosinophilia. The gene discussed is JAK2; the disease is acute myeloid leukemia.