FLT3 and acute myeloid leukemia: These JAK2 translocations (e.g., PCM1-JAK2, ETV6-JAK2, and BCR-JAK2) and FLT3 translocations (e.g., ETV6-FLT3, BCR-FLT3, and FLT3-TRIP11) are less common than PDGFRB translocations, generally manifesting as chronic myeloproliferative disease (e.g., CEL, aCML or CMML with eosinophilia), acute lymphoblastic leukemia, and very rarely as AML with eosinophilia.