SMAD4 and pancreatic intraductal papillary-mucinous neoplasm: There are several proposed factors that may increase the risk of post-resection recurrence and help guide post-resection surveillance patterns such as IPMN with low- or high-grade dysplasia, a margin-positive resection, certain genetic mutations (i.e., SMAD4, TP53 etc.), and having a family history of PDAC [2].