A major risk of using insulin pumps is the occurrence of diabetic ketoacidosis (DKA) due to malfunctioning of the pump, which can be limited by the use of continuous glycemic monitoring sensors, which have the capacity to alert the patient of CSII malfunctions through continuous detection of hypo/hyperglycemia in addition to the progressive improvements in patient education [59]. This evidence concerns the gene INS and Hyperglycemia.