A 2023 study from Guo et al. of CSII systems explored the effects of different insulin therapies in children with T1DM on diabetic retinopathy [69]: from the study where 42 participants were treated with multiple daily injections (MDI) of insulin and 22 with CSII, it emerged that patients treated with insulin pumps had a better vessel density than patients treated with MDI, suggesting that CSII may be a better choice for T1DM children to prevent retinal complication [69]. The gene discussed is INS; the disease is type 1 diabetes mellitus.