The authors provide an interesting overview of potential therapeutic strategies for tauopathies, and possibly glaucoma, including the suppression of microtubule-associated protein tau expression, the regulation of alternative splicing, the stabilization of microtubules, the regulation of post-translational modifications, the inhibition of aggregation, the activation of tau clearance, the use of passive or active immunization, and innovative approaches related to genome integrity preservation. Here, MAPT is linked to glaucoma.