In addition, DAO interactions with pharmaceutical drugs are crucial considerations in managing histamine-related conditions like fibromyalgia [19]; certain pharmaceutical drugs, like proton pump inhibitors (PPIs) [20] and non-steroidal anti-inflammatory drugs (NSAIDs) [21], have been reported to potentially inhibit DAO activity, impacting individuals with HIT and necessitating awareness of medication interactions [20,22]. The gene discussed is DAO; the disease is fibromyalgia.