Renal albumin excretion is <6% of its synthesis (<0.2% of the normative daily albumin turnover of 10.5 g) and increased urinary albumin excretion is now not only a factor in the progression of CKD, but is also associated with the presence of cardiac pathology and is associated with poor outcomes in patients with HF [17]. The gene discussed is ALB; the disease is chronic kidney disease.