During the last decades, thanks to a number of significant epidemiological investigations, high Lp(a) plasma levels have been definitely associated not only with a significant increased risk of atherosclerosis-related CV events (namely stroke, coronary artery disease, and peripheral artery disease) [3], but also with aortic stenosis and atrial fibrillation, after adjustments for other known risk factors [4,5]. This evidence concerns the gene LPA and coronary artery disorder.