Evidence suggests that the association between COPD and its comorbidities is the result of the ‘‘spill-over’’ of systemic inflammation in which Interleukin (IL)-6, IL-1β, C-reactive protein (CRP), and Tumor Necrosis Factor (TNF)-α play a primary role [1,2,3]. The gene discussed is IL1B; the disease is chronic obstructive pulmonary disease.