KLK3 and pachyonychia congenita: Univariate analysis found that patients diagnosed with PC under the age of 70 years, with a tumor stage of ≥T3, locoregional lymph node involvement (N1) or de novo distant metastasis, a prostate specific antigen (PSA) greater than 20 ng/mL, or a Gleason score >8 were at increased risk for developing visceral metastasis (VM) [38].