Tumor suppressors such as the retinoblastoma protein (RB1), tumor protein 53 (TP53), and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) repress lineage plasticity, ADT resistance, and metastasis in PC; accordingly, these genes are often mutated or lost in ADT-recurrent PCs [81,82,83,84]. This evidence concerns the gene RB1 and pachyonychia congenita.