Various poor prognostic factors in MDA5+-DM with ILD have been identified, including older age at disease onset, skin involvement, higher levels of lactose dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), ferritin, interleukin (IL)-6, and serum tumor markers, etc. [10,11]. This evidence concerns the gene CRP and dermatomyositis.