Numerous studies dealing with the risk factors for RPILD in DM patients have revealed that old age, elevated LDH, ferritin, CEA, CA-153, and CRP, the presence of anti-Ro52 antibodies, a high titer of anti-MDA5 antibodies, as well as a short disease duration of less than 3 months are the key risk factors [30,31,32]. Here, TRIM21 is linked to dermatomyositis.