Concomitantly, the ECMO circuit can induce bleeding associated with thrombocytopenia, platelet dysfunction, shear-mediated loss of high molecular weight von Willebrand factor (VWF) multimers, hypofibrinogenemia, coagulation factor (F) consumption (including FXIII) and inflammation [4,5]. This evidence concerns the gene VWF and Hypofibrinogenemia.