Miyashiro and Sanches reported that total IgE levels were above the normal range in all CTCL patients, but values were not pronounced enough to be a significant finding, while Khaled et al. found that significantly increased IgE levels were present in 25% of patients with CTCL-induced erythroderma [2,31]. The gene discussed is IGHE; the disease is exfoliative dermatitis.