FN1 and Alzheimer disease: In another study performed with S. aureus isolates from patients with AD, Cho et al. (2001) demonstrate that strains expressing collagen-binding adhesin as well as fibronectin-binding proteins were better able to adhere to stratum corneum isolated from AD patients as compared to healthy skin as well as bacteria that could not express adhesins required to bind to either collagen (Cna) or fibronectin (Fnbps).