Based on the above evidence, this study used a case‒control method to analyze the relationship between SDF-1ɑ(also known as the chemokine CXCL12) or XRCC1 and RCC and further analyzed the expression of the SDF-1ɑ and XRCC1 genes in RCC via bioinformatics methods, which can provide new clues and references for the active prevention and treatment of RCC. Here, CXCL12 is linked to renal cell carcinoma.