In summary, although this study has several limitations, such as a small sample size and admission rate bias due to the two-way selectivity between patients and hospitals, which results in cases and controls not being a random sample of the whole population, and the lack of basic validation experiments on the SDF-1ɑ and XRCC1 genes, this study confirmed the downregulation of SDF-1ɑ expression and upregulation of XRCC1 expression in kidney cancer tissues by bioinformatic methods and integrated information from the TCGA database. This evidence concerns the gene CXCL12 and kidney cancer.