Although the rs1799782 locus of the XRCC1 gene, the rs1801157 locus of the SDF-1ɑ gene allele and the genotype were not significantly correlated with tumor location or stage, the difference in rs1799782 of the XRCC1 gene among the different pathohistological types may be key factors in the onset and pathological development of renal cell carcinoma. Here, XRCC1 is linked to hereditary clear cell renal cell carcinoma.