Therefore, this study analyzed and explored the relationship between genetic polymorphisms and RCC susceptibility from a genetic point of view to provide scientific biomarkers for the effective prevention of RCC and analyzed and studied the associations of SDF-1ɑ and XRCC1 gene polymorphisms with lifestyle habits in RCC to provide a scientific basis for the effective prevention of RCC development. The gene discussed is XRCC1; the disease is renal cell carcinoma.