The genetic polymorphisms of the rs1799782 locus of the XRCC1 gene and the rs1801157 locus of the SDF-1ɑ gene showed that patients with each genotype had fewer lymph node metastases and distant metastases; the clinical stages were mostly stage I and II; and the pathohistological type was mostly clear-cell renal cell carcinoma. This evidence concerns the gene CXCL12 and metastatic malignant neoplasm in the lymph nodes.