With the presence of RCC as the dependent variable, the rs17997821 locus of the XRCC1 gene, the rs1801157 locus of the SDF-1ɑ gene, smoking status, literacy level, holding urine, dyeing hair, exposure to pesticides, type of meat–vegetable combination, and labor intensity as the independent variables, the conditional logistic regression model was applied to investigate the associations between the polymorphisms of the SDF-1ɑ and XRCC1 genes and between lifestyle habits and RCC. Here, CXCL12 is linked to renal cell carcinoma.