Genetic inactivation of Clock and/or Bmal1 has been found to induce proliferative and malignant phenotypes in various cancers, such as colon cancer,57 tongue squamous cell carcinoma,58 pancreatic cancer,59 lung adenocarcinoma,4 breast cancer,60 hepatocellular carcinoma,61 nasopharyngeal carcinoma (NPC),62 and glioblastoma (GBM).63 Here, BMAL1 is linked to tongue squamous cell carcinoma.