APOE and dementia: A meta-analysis in non-dementia cohorts has shown that amyloid positivity, determined through amyloid PET imaging and CSF biomarkers, is exacerbated during aging in an APOE genotype-dependent manner (ε4/ε4 > ε3/ε4 = ε2/ε4 > ε3/ε3 > ε2/ε3 > ε2/ε2) [16].