MAPT and Alzheimer disease: In more detailed analysis of neuritic plaque score, AD tau pathology, and AGD-tau pathology (Table 2), neuritic plaque score was significantly (P < 0.0167 considered significant after multiple testing correction) lower in the presence of APOE2 (OR = 0.49, p = 0.015), but higher in the presence of APOE4 (OR = 4.86, p < 0.001) when adjusting for age and sex.