Of note, the presence of AD-tau lesions was significantly associated with lower MMSE scores only in the absence of AGD-tau pathology (β = − 2.56, p < 0.001), with a weaker and non-significant association for subjects with AGD-tau pathology (β = − 0.24, p = 0.82); however, this interaction did not reach statistical significance (p = 0.042). Here, MAPT is linked to Alzheimer disease.