APOE and Alzheimer disease: In full multivariable analysis adjusting for age, sex, and any other measure that was associated with the given AD-related molecule with P < 0.05 in unadjusted analysis, neuritic plaque score was significantly associated (p < 0.005 considered as significant) with increased levels of soluble, detergent-soluble, and insoluble Aβ42 (TBS: β = 1.23, p < 0.001; TBSX: β = 1.33, p < 0.001; FA: β = 13.03, p < 0.001), insoluble apoE (FA: β = 0.65, p < 0.001) and insoluble pTau-181 (FA: β = 0.31, p < 0.001).