In the AD-tau positive group without AGD-tau pathology, higher levels of insoluble Aβ40 (FA: β = 14.15, p < 0.001), apoE (FA: β = 1.41, p < 0.001), and pTau181 (FA: β = 0.60, p = 0.001) as well as detergent-soluble Aβ40 (TBSX: β = 1.31, p = 0.002), Aβ42 (TBSX: β = 1.07, p = 0.004) and apoE (TBSX: β = 0.22, p = 0.002) were observed in the APOE4 group compared to the APOE3 group. This evidence concerns the gene APOE and Alzheimer disease.