Although not quite significant, the presence of AGD-tau was negatively associated with insoluble levels of Aβ40 (FA: β = − 9.96, p = 0.070), Aβ42 (FA: β = − 13.29, p = 0.046) and pTau181 (FA: β = − 0.68, p = 0.026) after adjusting for age and sex in AD-tau positive cases. The gene discussed is MAPT; the disease is Alzheimer disease.