APOE4 remained significantly associated with detergent-soluble and insoluble Aβ42 levels compared to APOE3 in the mixed tau pathology group (TBSX: β = 2.98, p = 0.004; FA: β = 26.52, p = 0.008), which may be driven by AD-tau positivity as, out of 13 cases, 12 are AD-tau positive (Table 5). This evidence concerns the gene APOE and Alzheimer disease.