When segregating cases based on the presence or absence of AD-tau or AGD-tau pathology (Additional file 1: Table S7), cases with AD-tau pathology had higher levels of insoluble Aβ40, Aβ42, apoE, and pTau181 compared to those without AD-tau, particularly in the absence of AGD-tau (Fig. 2). This evidence concerns the gene APOE and Alzheimer disease.