To investigate the potential of the Drosophila models in assessing treatments for patients with KCNT1 epilepsy, five of the frontline anti-epilepsy drugs currently administered to patients with KCNT1 epilepsy which have been shown to reduce, but rarely stop, seizures in some patients were analysed for their effects on the seizure phenotype in our Drosophila models. This evidence concerns the gene KCNT1 and epilepsy.