Moreover, accumulation of p-tau and Aβ, together with elevated MHPG levels, is associated with lower cortical thickness in LC-projecting regions [115]. These aberrant processes may suggest overactivation of the LC-noradrenergic circuitry for increased noradrenaline levels and a high demand on the system in neurodegenerative diseases. Here, MAPT is linked to neurodegenerative disease.