Compared with saline controls, the cardiomyocyte area was enlarged in Ang II-induced cardiac hypertrophy, which was alleviated by TOR2A knockdown (Fig. 2a, b); heart weight, HW/BW, HW/TL, LW/BW, LVAWs, LVAWd, LVPWs, LVPWd, IVSs and IVSd were elevated in Ang II-infused rats and all of them were attenuated by TOR2A downregulation (Fig. 2c-l). Here, AGT is linked to cardiac hypertrophy.