Interestingly, we observe a similar transcriptional up-regulation of Aox1 and down-regulation of Uro, MFS2 and Eglp2, as well as similar phenotypes, i.e., elevated levels of uric acid, kidney stone formation and bloating, in both Yki flies and flies with activated PDGF/VEGF signaling in PCs. The gene discussed is NPPA; the disease is nephrolithiasis.