MBP and experimental autoimmune encephalomyelitis: It has been reported that gemfibrozil attenuates experimental autoimmune encephalomyelitis (EAE), an animal model of relapsing–remitting multiple sclerosis (RMS) in mice by inhibiting encephalitogenic of myelin basic protein (MBP)-primed T cells and switched the immune response from a Th1 to a Th2 profile independent of PPAR-α [13–16].