Measuring the expression of AR and SYN in human PCa (Fig. 1e) and TripleTg mouse prostate PCa tissues (the middle panel, Fig. 3f) showed significant reduction of nuclear AR expression in both PCa cells in human tissues isolated from patients treated with ABI and ENZ and Solid-PCa cells from TripleTg mice (Supplementary Fig. 3d). This evidence concerns the gene AR and urogenital neoplasm.