AR and posterior cortical atrophy: GSEA using DEGs of hMETtg+ cells of TripleTg versus those of DoubleTg samples further showed down-regulation of androgen signaling pathways with upregulation of Wnt/β-catenin signaling pathways (Fig. 4c and Supplementary Fig. 4i), consistent with our earlier observation of reduced nuclear AR and increased stabilized β-catenin expression in Solid-PCa cells of TripleTg mice (Fig. 3f).