AR and posterior cortical atrophy: However, lack of typical nuclear AR staining along with positive phosphorylated MET (pMET) and cytoplasmic β-catenin staining was observed in adjacent sections of the above CRPC tissues but not in primary PCa samples (Fig. 1e, please see the “Methods” section), reaffirming activating MET and β-catenin signaling pathways correlated with reduced nuclear AR expression in those human CRPC cells.