Given that MYC is a master regulator of ribosome biogenesis28, identifying increased MYC expression in Solid-PCa cells through activating Wnt/β-catenin signaling outlines a regulatory mechanism for aberrant activation of XPO1, ribosomal biogenesis, and protein synthesis pathways to promote PCa progression and DNPC development. The gene discussed is MYC; the disease is posterior cortical atrophy.