Specific occupancy of SP1 was identified in the SP1 binding sites within both the promoter and enhancer regions of the Xpo1 gene locus, but not the Untr4 locus, used as a negative control, in PCa cells isolated from TripleTg mice, and also not in PCa cells isolated from DoubleTg mice (Fig. 5c)30. Here, XPO1 is linked to posterior cortical atrophy.