IHC analyses using adjacent PCa tissues of TripleTg mice showed the higher expression of XPO1, MYC, RPL12, RPS16, and pS6 in Solid-PCa cells than Adeno-PCa cells (Fig. 4k), further supporting the above scRNA-seq results, and suggesting that Solid-PCa are derived from Adeno-PCa during tumor progression in TripleTg mice. This evidence concerns the gene XPO1 and posterior cortical atrophy.