HGF and prostate intraepithelial neoplasia: Based on the guidelines provided by “the New York Pathology Panel”18, we identified pathological lesions representing low and high-grade PIN (LGPIN, HGPIN), or intracystic adenocarcinomas in prostate tissues of 3-, 6-, or 9-month-old DoubleTg mice, respectively, (Fig. 2d and Supplementary Fig. 2b), demonstrating reciprocal activation of MET via HGF promoting PCa development.