Accordingly, increased expression of SP1 and peri-nuclear staining of XPO1 only showed in both prostatic Solid-PCa and lung metastatic tumor cells but not in Adeno-PCa cells of TripleTg mice and PCa samples of DoubleTg mice in adjacent tissue sections (Fig. 5a and Supplementary Fig. 5e). Here, SP1 is linked to posterior cortical atrophy.