In contrast to the neutral or positive role on T-cell and phagocytic immunity, increased local infiltration of natural killer (NK) cells after inhibition of Beclin-1, ATG5 or p62/Sequestosome 1 (SQSTM1) in melanoma cells correlated with increased expression of the chemokine C–C motif chemokine ligand 5 (CCL5) has been reported. Here, ATG5 is linked to melanoma.