CASP3 and melanoma: In addition, the caspase-3 direct activator raptinal, a bifluorene–dicarbaldehyde compound, induced pyroptosis in both human and mouse melanoma cell line models and delayed tumor growth in vivo; this study suggests that the release of damage-associated molecular patterns (DAMPs) and inflammatory cytokines is dependent on caspase activity and GSDME expression [83].